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单刚 教授
作者:  来源:  发布时间:2019年09月20日 10:27  浏览次数:

个人简历

基本信息

单刚,博士,美高梅注册送28-网上注册平台正规网址教授,药物化学专业博士生导师。2019年获得美高梅注册送28“齐鲁青年学者”称号。

电话: 15965613018

邮箱: gangshan@sdu.edu.cn

通讯地址:山东省济南市文化西路44号,美高梅注册送28-网上注册平台正规网址

工作经历

 

 

2019.06 – 至今    美高梅注册送28-网上注册平台正规网址, 药物化学专业, 教授、博士生导师                   

2018.04 – 2019.04  博士后 

                    哈佛大学医学院丹娜法伯癌症研究所

                   Dana Farber Cancer Institute

2015.09 – 2018.04 博士后

                   德国马普分子生理学研究所 

                   (Max Planck Institute of Molecular Physiology)

 

教育背景

2010.09 – 2015.07 清华大学美高梅 博士 

                   

2006.09 – 2010.07 美高梅注册送28-网上注册平台正规网址 学士

 

主要研究方向

1. 基于活性天然产物的药物化学研究;

2. 小分子化合物库的构建、表型筛选与靶点鉴定;

3. 基于肿瘤ROSHypoxia的药物化学研究。

承担课题

美高梅注册送28“齐鲁青年学者”科研启动基金

 

论文

1. G. Shan, J. Flegel, H. Li, C. Merten, S. Ziegler, A. P. Antonchick, H. Waldmann.* "C-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Novel Hedgehog Pathway Inhibitors " Angew. Chem. Int. Ed. 2018, 57, 14250-14254.

2. Z. Jia, G. Shan, C. G. Daniliuc, A. P. Antonchick, H. Waldmann.* "Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis" Angew. Chem. Int. Ed. 2018, 57, 14493-14497.

3. X.L. Yang+, G. Shan+, Z. Yang, G. Huang, C. Sheng, Y. Rao.* "One-pot Synthesis of Quaternary Carbon Centered Cyclobutanes via Pd(II)-catalyzed Cascade C(sp3)-H Activations" Chem. Comm. 2017, 53, 1534-1537.

4. X.L. Yang+, G. Shan+, L. Wang, Y. Rao.* " Recent advances in transition metal (Pd, Ni)-catalyzed C(sp3)H bond activation with bidentate directing groups" Tetrahedron Lett.  2016, 56, 819-836.

5. G. Shan, G. Huang, Y. Rao,* H. Zhang.* "Palladium-catalyzed ortho-selective C-H bond chlorination of aromatic ketones" Chin. Chem. Lett. 2015, 26, 1236-1240.

6. G. Shan, G. Huang, Y. Rao.* "Palladium-Catalyzed Unactivated β-Methylene C(sp3)-H Bond Alkenylation of Aliphatic Amides and Application in A Sequential C(sp3)-H/C(sp2)-H Bond Alkenylation" Org. Biomol. Chem. 2015, 13, 697-701.

7. S. Chen, G. Shan, P. Nie, Y. Rao.* "3-Alkyloxycyclobutanones as Useful Synthons for Heterocycle and Carbocycle Synthesis" Asian J. Org. Chem. 2015, 4, 16-26.

8. Y. Rao*, G. Shan, X. Yang. "Some Recent Advances in Transition-metal-catalyzed ortho SP2 C–H Functionalization Using Ru, Rh, and Pd" Science China Chemistry, 2014, 57, 930-944.

9. X. Yang+, G. Shan+, Y. Rao.* "Synthesis of 2-Aminophenols and Heterocycles by Ru Catalyzed Mono- and Double C-H Hydroxylation" Org. Lett. 2013, 15, 2334-2337.

10. G. Shan, X. Han, Y. Lin, S. Yu, Yu Rao.* "Broadening the Catalyst and Reaction Scope of Regio- and Chemoselective C-H Oxygenation: A Convenient and Scalable Approach to 2-Acylphenols by Intriguing Rh(II) and Ru(II) Catalysis " Org. Biomol. Chem. 2013, 11, 2318-2322.

11. G. Shan+, X. Yang+, Y. Zong, Y. Rao.* "An Efficient Palladium Catalyzed C-H Alkoxylation of Unactivated Methylene and Methyl Groups with Cyclic Hypervalent Iodine (I3+) Oxidants" Angew. Chem. Int. Ed. 2013, 52, 13606-13610.

12. X. Sun+, G. Shan+, Y. Sun, Y. Rao.* "A General Approach for Regio- and Chemoselective C-H Chlorination/Bromination of Electron-Deficient Arenes via Weak Coordination and A Preliminary Study of Priority Order of Relative Directing Group Ability" Angew. Chem. Int. Ed. 2013, 52, 4440-4444.  

13. G. Shan, X. Yang, L. Ma, Y. Rao.* "Pd-Catalyzed C-H Oxygenation with TFA/TFAA: Expedient Access to Oxygen-Containing Heterocycles and Late-Stage Drug Modification" Angew. Chem. Int. Ed. 2012, 51, 13070-13074.

14. Pengfei Liu, Gang Shan, Shi Chen, Y. Rao.* "A New Regio- and Stereoselective Synthesis of β- Enamino Ketones with 3-Ethoxycyclobutanones and Substituted Amines" Tetrahedron Lett. 2012, 53, 936-939.

15. G. Shan, X. Sun, Q. Xia, Y. Rao.* "A Facile Synthesis of Substituted 2-Alkylquinolines Through [3+3] Annulation between 3-Ethoxycyclobutanones and Aromatic Amines at Room Temperature" Org. Lett. 2011, 13, 5770-5773.

16. G. Shan, P. Liu, Y. Rao.* "A New Synthesis of Pyrazoles through Lewis Acid-Catalyzed-Union of 3-Ethoxycyclobutanones with Monosubstituted Hydrazines" Org. Lett. 2011, 13, 1746-1749.

 
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  人才简介

单刚 教授
发布日期:2019-09-20  浏览次数:

个人简历

基本信息

单刚,博士,美高梅注册送28-网上注册平台正规网址教授,药物化学专业博士生导师。2019年获得美高梅注册送28“齐鲁青年学者”称号。

电话: 15965613018

邮箱: gangshan@sdu.edu.cn

通讯地址:山东省济南市文化西路44号,美高梅注册送28-网上注册平台正规网址

工作经历

 

 

2019.06 – 至今    美高梅注册送28-网上注册平台正规网址, 药物化学专业, 教授、博士生导师                   

2018.04 – 2019.04  博士后 

                    哈佛大学医学院丹娜法伯癌症研究所

                   Dana Farber Cancer Institute

2015.09 – 2018.04 博士后

                   德国马普分子生理学研究所 

                   (Max Planck Institute of Molecular Physiology)

 

教育背景

2010.09 – 2015.07 清华大学美高梅 博士 

                   

2006.09 – 2010.07 美高梅注册送28-网上注册平台正规网址 学士

 

主要研究方向

1. 基于活性天然产物的药物化学研究;

2. 小分子化合物库的构建、表型筛选与靶点鉴定;

3. 基于肿瘤ROSHypoxia的药物化学研究。

承担课题

美高梅注册送28“齐鲁青年学者”科研启动基金

 

论文

1. G. Shan, J. Flegel, H. Li, C. Merten, S. Ziegler, A. P. Antonchick, H. Waldmann.* "C-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Novel Hedgehog Pathway Inhibitors " Angew. Chem. Int. Ed. 2018, 57, 14250-14254.

2. Z. Jia, G. Shan, C. G. Daniliuc, A. P. Antonchick, H. Waldmann.* "Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis" Angew. Chem. Int. Ed. 2018, 57, 14493-14497.

3. X.L. Yang+, G. Shan+, Z. Yang, G. Huang, C. Sheng, Y. Rao.* "One-pot Synthesis of Quaternary Carbon Centered Cyclobutanes via Pd(II)-catalyzed Cascade C(sp3)-H Activations" Chem. Comm. 2017, 53, 1534-1537.

4. X.L. Yang+, G. Shan+, L. Wang, Y. Rao.* " Recent advances in transition metal (Pd, Ni)-catalyzed C(sp3)H bond activation with bidentate directing groups" Tetrahedron Lett.  2016, 56, 819-836.

5. G. Shan, G. Huang, Y. Rao,* H. Zhang.* "Palladium-catalyzed ortho-selective C-H bond chlorination of aromatic ketones" Chin. Chem. Lett. 2015, 26, 1236-1240.

6. G. Shan, G. Huang, Y. Rao.* "Palladium-Catalyzed Unactivated β-Methylene C(sp3)-H Bond Alkenylation of Aliphatic Amides and Application in A Sequential C(sp3)-H/C(sp2)-H Bond Alkenylation" Org. Biomol. Chem. 2015, 13, 697-701.

7. S. Chen, G. Shan, P. Nie, Y. Rao.* "3-Alkyloxycyclobutanones as Useful Synthons for Heterocycle and Carbocycle Synthesis" Asian J. Org. Chem. 2015, 4, 16-26.

8. Y. Rao*, G. Shan, X. Yang. "Some Recent Advances in Transition-metal-catalyzed ortho SP2 C–H Functionalization Using Ru, Rh, and Pd" Science China Chemistry, 2014, 57, 930-944.

9. X. Yang+, G. Shan+, Y. Rao.* "Synthesis of 2-Aminophenols and Heterocycles by Ru Catalyzed Mono- and Double C-H Hydroxylation" Org. Lett. 2013, 15, 2334-2337.

10. G. Shan, X. Han, Y. Lin, S. Yu, Yu Rao.* "Broadening the Catalyst and Reaction Scope of Regio- and Chemoselective C-H Oxygenation: A Convenient and Scalable Approach to 2-Acylphenols by Intriguing Rh(II) and Ru(II) Catalysis " Org. Biomol. Chem. 2013, 11, 2318-2322.

11. G. Shan+, X. Yang+, Y. Zong, Y. Rao.* "An Efficient Palladium Catalyzed C-H Alkoxylation of Unactivated Methylene and Methyl Groups with Cyclic Hypervalent Iodine (I3+) Oxidants" Angew. Chem. Int. Ed. 2013, 52, 13606-13610.

12. X. Sun+, G. Shan+, Y. Sun, Y. Rao.* "A General Approach for Regio- and Chemoselective C-H Chlorination/Bromination of Electron-Deficient Arenes via Weak Coordination and A Preliminary Study of Priority Order of Relative Directing Group Ability" Angew. Chem. Int. Ed. 2013, 52, 4440-4444.  

13. G. Shan, X. Yang, L. Ma, Y. Rao.* "Pd-Catalyzed C-H Oxygenation with TFA/TFAA: Expedient Access to Oxygen-Containing Heterocycles and Late-Stage Drug Modification" Angew. Chem. Int. Ed. 2012, 51, 13070-13074.

14. Pengfei Liu, Gang Shan, Shi Chen, Y. Rao.* "A New Regio- and Stereoselective Synthesis of β- Enamino Ketones with 3-Ethoxycyclobutanones and Substituted Amines" Tetrahedron Lett. 2012, 53, 936-939.

15. G. Shan, X. Sun, Q. Xia, Y. Rao.* "A Facile Synthesis of Substituted 2-Alkylquinolines Through [3+3] Annulation between 3-Ethoxycyclobutanones and Aromatic Amines at Room Temperature" Org. Lett. 2011, 13, 5770-5773.

16. G. Shan, P. Liu, Y. Rao.* "A New Synthesis of Pyrazoles through Lewis Acid-Catalyzed-Union of 3-Ethoxycyclobutanones with Monosubstituted Hydrazines" Org. Lett. 2011, 13, 1746-1749.

 
下一条:张涛 教授

关闭


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