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  人才简介


马淑涛 教授
作者:  来源:  发布时间:2018年10月24日 10:45  浏览次数:

 

马淑涛,美高梅注册送28-网上注册平台正规网址教授,药物化学专业博士生导师。药物化学教研室主任,2002年获国务院政府特殊津贴。近五年,先后主持国家级课题2项(国家级重大重点项目)、省部级课题3项;获国家发明专利7项;发表SCI收录学术论文38篇。

一、主要研究方向

方向1. 基于靶点(如FtsZAcrBQS)的抗耐药菌小分子化合物的设计、合成及抗耐药菌活性研究;

方向2. 复杂结构抗生素(如大环内酯、糖肽和脂肽类等)的结构修饰和构效关系研究; 

方向3. 重要天然产物和小分子肽的全合成及相关生物活性研究。 

二、标志性成果

(一)承担重大课题

1.“重大新药创制科技重大专项十一五计划项目,2009ZX09103- 115,基于细菌核糖体50S亚基多靶点设计、合成和优化抗耐药菌大环内酯候选药物。2009/01–2011/12150万元,课题主持人。

2.国家自然科学基金面上项目,81673284,抗菌苯甲酰胺类FtsZ抑制剂的设计、合成与生物活性研究,2017/01–2020/1261万元,课题主持人。

3.国家自然科学基金面上项目,21072114,抗耐药菌氮杂内酯先导物的发现和作用机制研究,2011/01–2013/1236万元,课题主持人。

(二)主编教材及著作

1.《药物化学(案例版)》第一版,副主编,科学出版社,北京,2010年。

(三)获奖情况

1.马淑涛(1/6),阿奇霉素及胶囊剂的研究,山东省科技厅,一等奖,2000

2.马淑涛,国务院政府特殊津贴,中华人民共和国国务院,2002

3.马淑涛,第七届山东省青年科技奖,山东省组织部、人事厅和科学技术协会,2002

(四) 代表性学术论文 (限10篇)

1.Yinhu Wang, Rumana Mowla, Shengli Ji, Liwei Guo, Miguel A. De Barros Lopes, Chaobin Jin, Di Song, Shutao Ma*, Henrietta Venter. Design, synthesis and biological activity evaluation of novel 4-subtituted 2-naphthamide derivatives as AcrB inhibitors. Eur. J. Med. Chem. 2018, 143: 699–709.

2.Mi Yan, Ruixin Ma, Li Jia, Henrietta Venter, Shutao Ma*. Synthesis and antibacterial activity of novel 3-O-descladinosyl azithromycin derivatives. Eur. J. Med. Chem. 2017, 127: 874–884.

3.Xin Li, Juzheng Sheng, Guihua Huang, Ruixin Ma, Fengxin Yin, Di Song, Can Zhao, Shutao Ma*. Design, synthesis and antibacterial activity of cinnamaldehyde derivatives as inhibitors of the bacterial cell division protein FtsZ. Eur. J. Med. Chem. 2015, 97: 32–47.

4.Mi Yan, Xiaodong Ma, Ruiqian Dong, Xin Li, Can Zhao, Zhenzhen Guo, Yan Shen, Fang Liu, Ruixin Ma, Shutao Ma*. Synthesis and antibacterial activity of 4"-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. Eur. J. Med. Chem. 2015, 103: 506–515.

5. Xin Li, Siti Ma, Mi Yan, Yuanze Wang, Shutao Ma*. Synthesis and antibacterial evaluation of novel 11,4?-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria. Eur. J. Med. Chem. 2013, 59: 209–217.

6.Sean M. DeGuire, Shutao Ma, Gary A. Sulikowski. Synthesis of a bicyclobutane fatty acid identified from the cyanobacterium anabaena PCC 7120. Angew. Chem. Int. Ed., 2011, 50: 9940–9942.

7.Xiaodong Ma, Ling Zhang, Rongmei Wang, Jichao Cao, Chen Liu, Yi Fang, Jida Wang, Shutao Ma*. Novel C-4? modified azithromycin analogs with remarkably enhanced activity against erythromycin-resistant Streptococcus pneumoniae: The synthesis and antimicrobial evaluation. Eur. J. Med. Chem. 2011, 46: 5196–5205.

8.Chao Cong, Haiyang Wang, Yue Hu, Chen Liu, Siti Ma, Xin Li, Jichao Cao, Shutao Ma*. Synthesis and antibacterial activity of novel 4?-O-benzimidazolyl clarithromycin derivatives. Eur. J. Med. Chem. 2011, 46: 3105–3111.

9.Shutao Ma*, Bo Jiao, Yongjing Ju, Manjie Zheng, Ruixin Ma, Lin Liu, Ling Zhang, Xuecui Shen, Chenchen Ma, Ya Meng, Hui Wang, Yunkun Qi, Xiaodong Ma, Wenping Cui. Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4? elongated arylalkyl groups against macrolide-resistant strains. Eur. J. Med. Chem. 2011, 46: 556–566.

10.Ling Zhang, Linchen Song, Zhaopeng Liu, Hui Li, Yingdong Lu, Zerong Li, Shutao Ma*. Synthesis and antibacterial activity of novel 3-O-carbamoyl derivatives of clarithromycin and 11,12-cyclic carbonate azithromycin. Eur. J. Med. Chem. 2010, 45: 915–922.

 
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  人才简介

马淑涛 教授
发布日期:2018-10-24  浏览次数:

 

马淑涛,美高梅注册送28-网上注册平台正规网址教授,药物化学专业博士生导师。药物化学教研室主任,2002年获国务院政府特殊津贴。近五年,先后主持国家级课题2项(国家级重大重点项目)、省部级课题3项;获国家发明专利7项;发表SCI收录学术论文38篇。

一、主要研究方向

方向1. 基于靶点(如FtsZAcrBQS)的抗耐药菌小分子化合物的设计、合成及抗耐药菌活性研究;

方向2. 复杂结构抗生素(如大环内酯、糖肽和脂肽类等)的结构修饰和构效关系研究; 

方向3. 重要天然产物和小分子肽的全合成及相关生物活性研究。 

二、标志性成果

(一)承担重大课题

1.“重大新药创制科技重大专项十一五计划项目,2009ZX09103- 115,基于细菌核糖体50S亚基多靶点设计、合成和优化抗耐药菌大环内酯候选药物。2009/01–2011/12150万元,课题主持人。

2.国家自然科学基金面上项目,81673284,抗菌苯甲酰胺类FtsZ抑制剂的设计、合成与生物活性研究,2017/01–2020/1261万元,课题主持人。

3.国家自然科学基金面上项目,21072114,抗耐药菌氮杂内酯先导物的发现和作用机制研究,2011/01–2013/1236万元,课题主持人。

(二)主编教材及著作

1.《药物化学(案例版)》第一版,副主编,科学出版社,北京,2010年。

(三)获奖情况

1.马淑涛(1/6),阿奇霉素及胶囊剂的研究,山东省科技厅,一等奖,2000

2.马淑涛,国务院政府特殊津贴,中华人民共和国国务院,2002

3.马淑涛,第七届山东省青年科技奖,山东省组织部、人事厅和科学技术协会,2002

(四) 代表性学术论文 (限10篇)

1.Yinhu Wang, Rumana Mowla, Shengli Ji, Liwei Guo, Miguel A. De Barros Lopes, Chaobin Jin, Di Song, Shutao Ma*, Henrietta Venter. Design, synthesis and biological activity evaluation of novel 4-subtituted 2-naphthamide derivatives as AcrB inhibitors. Eur. J. Med. Chem. 2018, 143: 699–709.

2.Mi Yan, Ruixin Ma, Li Jia, Henrietta Venter, Shutao Ma*. Synthesis and antibacterial activity of novel 3-O-descladinosyl azithromycin derivatives. Eur. J. Med. Chem. 2017, 127: 874–884.

3.Xin Li, Juzheng Sheng, Guihua Huang, Ruixin Ma, Fengxin Yin, Di Song, Can Zhao, Shutao Ma*. Design, synthesis and antibacterial activity of cinnamaldehyde derivatives as inhibitors of the bacterial cell division protein FtsZ. Eur. J. Med. Chem. 2015, 97: 32–47.

4.Mi Yan, Xiaodong Ma, Ruiqian Dong, Xin Li, Can Zhao, Zhenzhen Guo, Yan Shen, Fang Liu, Ruixin Ma, Shutao Ma*. Synthesis and antibacterial activity of 4"-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. Eur. J. Med. Chem. 2015, 103: 506–515.

5. Xin Li, Siti Ma, Mi Yan, Yuanze Wang, Shutao Ma*. Synthesis and antibacterial evaluation of novel 11,4?-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria. Eur. J. Med. Chem. 2013, 59: 209–217.

6.Sean M. DeGuire, Shutao Ma, Gary A. Sulikowski. Synthesis of a bicyclobutane fatty acid identified from the cyanobacterium anabaena PCC 7120. Angew. Chem. Int. Ed., 2011, 50: 9940–9942.

7.Xiaodong Ma, Ling Zhang, Rongmei Wang, Jichao Cao, Chen Liu, Yi Fang, Jida Wang, Shutao Ma*. Novel C-4? modified azithromycin analogs with remarkably enhanced activity against erythromycin-resistant Streptococcus pneumoniae: The synthesis and antimicrobial evaluation. Eur. J. Med. Chem. 2011, 46: 5196–5205.

8.Chao Cong, Haiyang Wang, Yue Hu, Chen Liu, Siti Ma, Xin Li, Jichao Cao, Shutao Ma*. Synthesis and antibacterial activity of novel 4?-O-benzimidazolyl clarithromycin derivatives. Eur. J. Med. Chem. 2011, 46: 3105–3111.

9.Shutao Ma*, Bo Jiao, Yongjing Ju, Manjie Zheng, Ruixin Ma, Lin Liu, Ling Zhang, Xuecui Shen, Chenchen Ma, Ya Meng, Hui Wang, Yunkun Qi, Xiaodong Ma, Wenping Cui. Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4? elongated arylalkyl groups against macrolide-resistant strains. Eur. J. Med. Chem. 2011, 46: 556–566.

10.Ling Zhang, Linchen Song, Zhaopeng Liu, Hui Li, Yingdong Lu, Zerong Li, Shutao Ma*. Synthesis and antibacterial activity of novel 3-O-carbamoyl derivatives of clarithromycin and 11,12-cyclic carbonate azithromycin. Eur. J. Med. Chem. 2010, 45: 915–922.

 
上一条:赵桂森 教授
下一条: 李孝训 教授

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